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Related Experiment Video

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Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
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Using Goldmann Visual Field Volume to Track Disease Progression in Choroideremia.

Adam P DeLuca1, S Scott Whitmore1, Nicole J Tatro1

  • 1The University of Iowa Institute for Vision Research & Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.

Ophthalmology Science
|November 29, 2023
PubMed
Summary
This summary is machine-generated.

A new computational method quantifies visual field loss in choroideremia patients using Goldmann visual field (GVF) data. This approach enables better tracking of disease progression and informs clinical trial designs for inherited retinal diseases.

Keywords:
ChoroideremiaGoldmann kinetic perimetryInherited retinal diseaseVisual fields

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Area of Science:

  • Ophthalmology and Visual Science
  • Computational Biology and Bioinformatics
  • Genetics and Genomics

Background:

  • Choroideremia is an X-linked choroidopathy caused by pathogenic variants in the CHM gene.
  • Characterized by progressive peripheral visual field loss, monitoring disease progression is challenging.
  • Existing methods struggle with quantitative assessment due to variable data collection protocols.

Purpose of the Study:

  • To develop and validate a novel computational approach for quantifying visual field loss in choroideremia.
  • To convert traditional Goldmann visual field (GVF) data into quantitative volumetric measurements.
  • To analyze visual field loss progression in a retrospective cohort of choroideremia patients.

Main Methods:

  • Retrospective analysis of GVF and visual acuity (VA) data from 56 molecularly-confirmed male patients with choroideremia.
  • GVF data were digitized using a tablet application, and 3D 'hill of vision' was interpolated for volumetric quantification.
  • A delayed exponential mixed-effects model was employed to assess the rate of visual field volume loss over time.

Main Results:

  • The mean age of disease onset was estimated at 12.6 years.
  • Mean annual visual field volume loss was 6.8%, with significant inter-eye correlation (r² = 0.935).
  • Field volume loss showed a stronger correlation between eyes compared to best-corrected VA (r² = 0.285).

Conclusions:

  • Volumetric analysis of GVF data provides a robust method for quantifying peripheral visual function and disease progression in choroideremia.
  • This computational approach can standardize and analyze historical GVF data, aiding research in inherited retinal diseases.
  • The findings support the development of appropriate outcome measures for choroideremia therapeutic trials.