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Updated: Jul 9, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Extracellular vesicles modulate key signalling pathways in refractory wound healing.
Bowen Yang1, Yumeng Lin1, Yibo Huang1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041, China.
Extracellular vesicles (EVs) from stem cells significantly enhance chronic wound healing and reduce scarring by modulating key cellular pathways. This review explores their therapeutic potential and future directions for improved efficacy.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Wound Healing Research
Background:
- Chronic wounds pose significant challenges and economic burdens due to impaired healing.
- Extracellular vesicles (EVs) from stem/progenitor cells show promise in promoting wound repair.
- EVs are cell-derived particles carrying bioactive molecules that mediate intercellular communication.
Purpose of the Study:
- To review recent advances in extracellular vesicle (EV)-based wound healing therapies.
- To focus on signaling pathways modulated by EVs in wound repair and scar reduction.
- To discuss the potential and challenges of engineered EVs for enhanced wound healing.
Main Methods:
- Literature review of studies on extracellular vesicles (EVs) in wound healing.
- Analysis of signaling pathways (e.g., Wnt/β-catenin, PI3K/Akt/mTOR, VEGF, TGF-β, JAK-STAT) regulated by EVs.
- Examination of EV cargo and their role in modulating cellular processes.
Main Results:
- EVs from various stem/progenitor cells promote wound healing and reduce scarring.
- EVs modulate critical pathways including Wnt/β-catenin, PI3K/Akt/mTOR, VEGF, TGF-β, and JAK-STAT.
- EVs influence cell differentiation, angiogenesis, immune response, and tissue remodeling.
Conclusions:
- Extracellular vesicles (EVs) offer a promising therapeutic strategy for chronic wound management.
- Understanding EV-mediated signaling pathways is crucial for optimizing their wound healing potential.
- Engineering EVs presents opportunities to enhance their efficacy and specificity for clinical applications.
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