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Sciatic diffuse large B-cell lymphoma with treatment response to CHOP and radiotherapy
Firoozeh Shomal Zadeh1, Ayimen Khalid Khan1, Atefe Pooyan1
1Musculoskeletal Imaging and Intervention, Department of Radiology, University of Washington, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105, USA.
Radiology Case Reports
|November 29, 2023
Summary
This case study details neurolymphomatosis affecting the sciatic nerve, a rare lymphoma complication. Early diagnosis and treatment with chemotherapy and radiotherapy are crucial for managing this condition.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Neurolymphomatosis is a rare manifestation of lymphoma involving the peripheral nervous system.
- It can present with diverse neurological symptoms, making diagnosis challenging.
Observation:
- A 41-year-old woman presented with acute sciatic nerve pain, progressing to paresthesia and weakness.
- MRI revealed a lobulated sciatic nerve mass with central necrosis; PET-CT showed avid FDG uptake.
Findings:
- A diagnosis of diffuse large B-cell lymphoma was confirmed via biopsy after tumor resection.
- The imaging characteristics were consistent with a malignant neoplastic process.
Implications:
- This case highlights the importance of considering neurolymphomatosis in the differential diagnosis of unexplained peripheral neuropathies.
- Multimodal imaging and biopsy are essential for accurate diagnosis and timely initiation of treatment, including chemotherapy and radiotherapy.
