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Brachial-ankle pulse wave velocity increasing with heart rate accelerates

Qian Wang1, Xinxin Xu2, Xue Geng1

  • 1Department of Cardiovascular Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Frontiers in Cardiovascular Medicine
|November 29, 2023
PubMed

Insights

Pulse wave velocity (PWV), a measure of vascular stiffness, increases with heart rate (HR) in pacemaker patients. Higher heart rates are associated with higher brachial-ankle PWV, indicating greater arterial stiffness.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Biomedical Engineering

Background:

  • Pulse wave velocity (PWV) is a key indicator of arterial stiffness.
  • Pacemaker implantation is common in patients with cardiac conditions.
  • Understanding factors influencing PWV in these patients is crucial for cardiovascular health assessment.

Purpose of the Study:

  • To investigate the relationship between heart rate (HR) and brachial-ankle pulse wave velocity (ba-PWV).
  • To explore this association in patients dependent on pacemakers.
  • To determine if changes in HR affect ba-PWV measurements.

Main Methods:

  • Retrospective observational study of 68 pacemaker-dependent patients.
  • ba-PWV measurements were collected at various set heart rates (60-100 bpm).
  • Statistical analysis, including generalized estimating equations, adjusted for clinical factors.

Main Results:

  • Significant differences in ba-PWV and diastolic blood pressure were observed across different HRs (P < 0.001).
  • ba-PWV was independently associated with HR after adjusting for SBP, DBP, age, and sex.
  • Higher HR coefficients indicated increased ba-PWV with accelerating heart rates.

Conclusions:

  • Heart rate significantly influences brachial-ankle pulse wave velocity measurements.
  • In pacemaker patients, elevated heart rates correlate with increased arterial stiffness.
  • These findings highlight the importance of considering HR when interpreting ba-PWV in pacemaker-dependent individuals.

Keywords:
arterial stiffnessblood pressureheart ratepacemakerpulse wave velocity

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