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Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

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Updated: Jul 9, 2025

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Thrombotic triad in microgravity.

Mohammad M Elahi¹, Alexandra N Witt², Edward L G Pryzdial²

¹Faculty of Medicine, University of British Columbia, Canada; Centre for Blood Research, Life Sciences Institute, University of British Columbia, Canada.

Thrombosis Research

|November 29, 2023

Summary

This summary is machine-generated.

Spaceflight may increase the risk of thrombotic disease due to microgravity effects on blood flow and coagulation. Astronauts show venous flow risk factors, highlighting the need for further research into space thrombosis.

Keywords:

Blood flow stasis Coagulation Microgravity Thrombosis Virchow's triad

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Last Updated: Jul 9, 2025

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Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Area of Science:

Space Medicine
Cardiovascular Physiology
Thrombosis Research

Background:

Thrombotic disease is a potential risk for astronauts exposed to microgravity.
Underlying factors contributing to space-related thrombosis are not well-defined.
A case of internal jugular vein thrombosis in an astronaut after a 7-week mission highlights this concern.

Purpose of the Study:

To review existing literature on thrombotic disease in the context of space travel.
To explore the potential impact of microgravity on blood flow stasis, coagulation, and vascular function.
To consider the elements of Virchow's triad in relation to spaceflight-induced thrombosis.

Main Methods:

Literature review of thrombotic disease in space.
Analysis of jugular venous flow risk factors observed in astronauts.
Consideration of microgravity studies (in-space and Earth-based simulations).

Main Results:

One low-risk astronaut developed internal jugular vein thrombosis after a 7-week mission.
Six of ten other crew members exhibited jugular venous flow risk factors (stasis, retroversion).
Microgravity studies suggest impacts on blood flow stasis, coagulation, and vascular function.

Conclusions:

Prolonged microgravity exposure may lead to underdiagnosed thrombotic disease in astronauts.
Venous flow abnormalities are observable in space crews, even if asymptomatic.
Further investigation into Virchow's triad components is crucial for understanding and mitigating space thrombosis risks.