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Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
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Wnt pathway in bone: knowledge structure and hot spots from 1993 to 2022
Tun Liu1, Jiaxin Zhao1, Xinyi Zhang1
1The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Frontiers in Physiology
|November 30, 2023
Summary
This bibliometric study analyzes Wnt signaling in bone research, revealing key trends and leading contributors. It highlights current hotspots like bone mass and sclerostin antibody, guiding future skeletal disease studies.
Area of Science:
- Bone Biology and Skeletal Diseases
- Molecular Signaling Pathways
- Bibliometric Analysis
Background:
- The Wnt signaling pathway is crucial for bone biology and skeletal diseases.
- A systematic analysis of Wnt pathway research in bone is lacking.
- This study addresses this gap by analyzing publication trends.
Purpose of the Study:
- To conduct a bibliometric analysis of Wnt signaling pathway research in bone.
- To describe the current state of research and identify future trends.
- To provide insights for researchers and clinicians in skeletal-related studies.
Main Methods:
- Collected 7,184 articles and reviews from 1993-2022 from Web of Science Core Collection.
- Utilized CiteSpace, VOSviewer, and an online platform for bibliometric analysis.
- Identified leading countries, institutions, authors, journals, and keywords.
Main Results:
- Publication peaked in 2021, with China and the US as leading countries.
- Key research areas include Wnt expression, osteoporosis, and osteogenic differentiation.
- Emerging hotspots are bone mass, sclerostin antibody, multiple myeloma, and cartilage development.
Conclusions:
- This bibliometric analysis offers insights into Wnt and bone research.
- It identifies key mechanisms and potential clinical translation avenues.
- The study outlines development and future trends in Wnt and skeletal research.
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