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Association between excess catecholamine synthesis and polymorphic premature ventricular contraction
Burak Cesur1, Deniz Elcik2, Zeki Cetinkaya2
1Kayseri State Hospital, Department of Cardiology, Kayseri, Turkey.
Journal of Electrocardiology
|November 30, 2023
Summary
High catecholamine levels, including adrenaline and noradrenaline, are linked to frequent premature ventricular contractions (PVCs). Increased PVCs correlate with elevated levels of these hormones, suggesting a potential etiological factor.
Area of Science:
- Cardiology
- Endocrinology
- Clinical Research
Background:
- Etiology of premature ventricular contractions (PVCs) is not fully understood.
- Many patients exhibit resistance to medical treatments for PVCs.
- Predictive factors for treatment response in PVC patients remain elusive.
Purpose of the Study:
- To investigate the association between elevated catecholamine levels and polymorphic PVC.
- To determine if high adrenaline and noradrenaline levels contribute to PVC development.
Main Methods:
- Prospective data registry analysis of 100 patients (50 PVC group, 50 control).
- Inclusion criteria for PVC group: >=5% polymorphic PVC in 24-h Holter monitoring.
- Urine samples analyzed for metanephrine (adrenaline) and normetanephrine (noradrenaline) levels.
Main Results:
- Significantly higher normetanephrine levels in the PVC group (323.9 ± 208.9 μg) vs. control (129.25 ± 67.88 μg; p < 0.001).
- Significantly higher metanephrine levels in the PVC group (124.75 ± 82.43 μg) vs. control (52.615 ± 36.54 μg; p < 0.001).
- Moderate positive correlation observed between PVC frequency/ratio and metanephrine/normetanephrine levels.
Conclusions:
- Catecholamine levels are elevated in patients with frequent polymorphic PVC compared to healthy individuals.
- Increased PVC occurrence and rate are associated with rising catecholamine levels.
- High catecholamine levels may play a role in the etiology of polymorphic PVC.
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