Related Experiment Video

Updated: Jul 9, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Tumor Suppressive Role of MicroRNAs in Triple Negative Breast Cancer

Acharya Balkrishna1, Rashmi Mittal1, Vedpriya Arya1

  • 1Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar, India.

Current Pharmaceutical Design
|December 1, 2023
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive and lacks effective treatments. MicroRNAs (miRNAs) show therapeutic potential by targeting TNBC

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous cancer subtype with high recurrence rates and limited therapeutic options.
  • The tumor microenvironment in TNBC, including cancer-associated fibroblasts and epithelial-mesenchymal transition, promotes disease progression and metastasis.
  • MicroRNAs (miRNAs) are emerging as key regulators with oncogenic or tumor-suppressive roles in TNBC development.

Conclusions:

  • miRNAs represent a promising avenue for novel therapeutic strategies against triple-negative breast cancer.
  • Targeting miRNAs can modulate the complex tumor microenvironment, potentially inhibiting TNBC progression and metastasis.
  • Further research into miRNA-based diagnostics and therapeutics is warranted for improved TNBC patient management.
Keywords:
CAFsCSCsEMTTMETNBCmiRNAsprognosistherapeutic.

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