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Split ring multiband refractive index cancer sensor based on terahertz radiation.

Zhengzheng Li

    Applied Optics
    |December 1, 2023
    PubMed
    Summary

    This study introduces a novel multiband terahertz (THz) metamaterial biosensor for early cancer detection. The proposed THz biosensor achieves high absorptivity and exceptional sensitivity for detecting various cancer cells.

    Area of Science:

    • Metamaterials
    • Biosensing
    • Terahertz (THz) technology

    Background:

    • Early cancer detection remains a critical challenge in healthcare.
    • Existing biosensing technologies face limitations in sensitivity and specificity.
    • Terahertz (THz) metamaterials offer unique properties for label-free biosensing applications.

    Purpose of the Study:

    • To propose and analyze a novel multiband THz metamaterial biosensor for early cancer detection.
    • To optimize the sensor's performance by tuning design parameters for high absorptivity and polarization independence.
    • To evaluate the sensor's sensitivity to different cell types, including cancerous and non-cancerous cells.

    Main Methods:

    • Design and simulation of a multiband THz metamaterial biosensor with arc-shaped structures.

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  • Analysis of absorption spectrum and polarization independence under varying design parameters.
  • Investigation of the influence of sample refractive index and thickness on sensor performance.
  • Theoretical calculation of sensor sensitivity to basal, breast, and cervical cells and their cancerous counterparts.

    • Main Results:

    • The proposed THz biosensor operates at three distinct frequencies with absorptivity exceeding 99% in free space.
    • Optimization of design parameters enhanced the sensor's absorption characteristics.
    • The sensor demonstrated high sensitivity to refractive index changes, crucial for biosensing.
    • Maximum sensitivity reached 642.5 GHz/RIU, significantly outperforming existing biosensors.

    Conclusions:

    • The developed multiband THz metamaterial biosensor shows great potential for early cancer detection and warning.
    • The sensor's high sensitivity and label-free detection capabilities make it a promising tool for biomedical applications.
    • Further research can explore in vivo applications and integration into clinical diagnostic platforms.