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Anti-inflammatory Effects of Compounds Extracted from Marine Sponge s: A Systematic Review
Angela Maria Paiva Magri1,2, Ingrid Regina Avanzi1, Guilherme Trindade Vila2
1Department of Biosciences, Federal University of São Paulo (UNIFESP), Rua Silva Jardim, 136, Santos, SP, 11015020, Brazil.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
|December 1, 2023
Summary
Marine sponges yield natural anti-inflammatory compounds with drug development potential. This review highlights 251 bioactive compounds and their therapeutic promise for inflammatory conditions.
Area of Science:
- Marine Biotechnology
- Natural Product Chemistry
- Pharmacology
Background:
- Marine sponges are recognized sources of natural anti-inflammatory substances.
- These compounds hold significant biotechnological potential for novel drug development.
Approach:
- A systematic review was conducted using Embase, PubMed, Scopus, and Web of Science.
- 100 eligible manuscripts were identified from an initial search, with 83 ultimately included in the analysis.
Key Points:
- Investigated 251 bioactive compounds from marine sponges for anti-inflammatory effects.
- Assessed compounds using both in vivo and in vitro assays.
- Identified inhibition of key pro-inflammatory mediators including TNF-α, IL-6, NO, iNOS, COX-2, IL-1β, PGE2, PLA2, NF-κB, LTB4, COX-1, and superoxide radicals.
Conclusions:
- Marine sponge-derived substances show significant promise for developing new anti-inflammatory drugs.
- These compounds may offer therapeutic potential for various pathological conditions.
- Approximately 98% of reviewed articles support the anti-inflammatory potential of marine sponge-derived substances.
