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Updated: Jul 9, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Emerging treatment approaches for triple-negative breast cancer

Maurizio Capuozzo1, Venere Celotto1, Mariachiara Santorsola2

  • 1Pharmaceutical Department, ASL Napoli 3, Ercolano, 80056, Naples, Italy.

Medical Oncology (Northwood, London, England)
|December 1, 2023
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies. This review explores emerging treatments like PARP inhibitors and immunotherapy, offering new hope for TNBC patients.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Triple-negative breast cancer (TNBC) accounts for 15% of global cases.
  • TNBC is the most aggressive subtype due to the absence of estrogen receptor, progesterone receptor, and HER2.
  • This profile limits treatment options, excluding hormone and anti-HER2 therapies.

Purpose of the Study:

  • To review standard and emerging therapies for TNBC.
  • To explain the mechanisms and clinical applications of novel treatments.
  • To contextualize these advancements within current TNBC treatment paradigms.

Main Methods:

  • Literature review of standard and emerging TNBC therapies.
  • Exploration of drug mechanisms of action.
  • Analysis of clinical utilization and future prospects.

Main Results:

  • Standard therapies are limited for TNBC.
  • Emerging approaches include PARP inhibitors, immune checkpoint inhibitors, PI3K/AKT pathway inhibitors, and antibody-drug conjugates.
  • These therapies offer promising avenues for tailored interventions.

Conclusions:

  • TNBC presents a significant challenge in oncology.
  • Emerging therapies show potential to improve patient outcomes.
  • TNBC serves as a model for translational research and innovative oncology treatments.
Keywords:
ImmunotherapyPARP inhibitorsPrognosisTriple-negative breast cancer

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