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Minimal Peptoid Dynamics Inform Self-Assembly Propensity.

Hamish W A Swanson1, King Hang Aaron Lau1, Tell Tuttle1

  • 1Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, U.K.

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Peptoid side chain dynamics influence self-assembly into ordered nanostructures. Homogeneous sampling of backbone torsions correlates with assembly ability, offering insights into designing novel nanomaterials.

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Area of Science:

  • Supramolecular Chemistry
  • Computational Chemistry
  • Materials Science

Background:

  • Peptoids, peptide isomers with amide nitrogen side-chain attachment, exhibit unique conformational flexibility.
  • Minimal peptoids with aromatic side chains self-assemble into ordered nanostructures.
  • Understanding the relationship between peptoid dynamics and assembly is crucial for materials design.

Purpose of the Study:

  • To develop descriptors for intramolecular dynamics of aromatic side chains in peptoids.
  • To investigate the correlation between side chain dynamics and experimentally observed nanoscale self-assembly.
  • To draw parallels between peptoid and peptide self-assembly mechanisms.

Main Methods:

  • Development and refinement of an atomistic peptoid force field (CGenFF-WS).
  • Rigorous fitting of partial charges and collation of relevant CGenFF parameters.
  • Employing a variety of computational approaches to assess intramolecular dynamics and sampling.

Main Results:

  • Intramolecular side chain dynamics depend on backbone ω torsion combinations.
  • Homogeneity of torsional sampling correlates strongly with the ability to form ordered nanomorphologies.
  • Sequence patterning affects sampling similarly in both tripeptoids and tripeptides.

Conclusions:

  • Side chain dynamics and conformational sampling are key determinants of peptoid self-assembly.
  • Homogeneous sampling across backbone torsions promotes long-range ordered nanostructure formation.
  • Identified structural motifs may be relevant for designing extended linear assemblies.