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Long-acting inhaled medicines: Present and future
Chengqian Zhang1, Davide D'Angelo2, Francesca Buttini3
1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Advanced Drug Delivery Reviews
|December 1, 2023
Summary
Long-acting inhaled medicines (LAIM) improve patient compliance and treatment effectiveness for respiratory conditions. This review covers advances, technologies, and challenges in developing these crucial long-acting inhaled therapies.
Area of Science:
- Pulmonary Medicine
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Inhaled medicines are vital for managing respiratory diseases like asthma, COPD, and cystic fibrosis.
- Inhalation technology offers advantages including rapid action, enhanced bioavailability, and reduced side effects.
- Current research focuses on delivery, particle engineering, devices, and digital health, alongside extending drug action duration.
Purpose of the Study:
- To review advancements in long-acting inhaled medicines (LAIM).
- To explore pharmaceutical technologies and strategies for developing LAIM.
- To discuss emerging long-acting inhaled modalities and future development challenges.
Main Methods:
- Literature review of scientific publications on inhaled medicines and LAIM.
- Analysis of pharmaceutical technologies and strategies for prolonging drug action.
- Examination of emerging inhaled modalities and their therapeutic potential.
Main Results:
- LAIM enhance patient compliance by reducing dosing frequency.
- LAIM improve the effectiveness and convenience of inhaled therapies.
- New pharmaceutical strategies are being developed to create effective LAIM.
Conclusions:
- LAIM represent a significant advancement in respiratory disease management.
- Continued innovation in pharmaceutical technologies is crucial for future LAIM development.
- Addressing challenges in LAIM development will expand treatment options for various diseases.
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