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Related Experiment Video

Updated: Jul 9, 2025

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels

Published on: October 20, 2023

An easy-to-implement, non-invasive head restraint method for monkey fMRI.

Reiji Tanaka¹, Kei Watanabe², Takafumi Suzuki³

¹Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan; Japan Society for the Promotion of Science (JSPS), Tokyo, Japan.

|December 1, 2023

Summary

This summary is machine-generated.

Researchers developed a non-invasive plastic head mask for functional magnetic resonance imaging (fMRI) in monkeys. This method effectively reduces head movement and improves data quality compared to traditional invasive head-posts.

Keywords:

Monkey fMRI non-invasive

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Area of Science:

Neuroscience
Primate Research
Medical Imaging

Background:

Functional magnetic resonance imaging (fMRI) in behaving monkeys is crucial for bridging human neuroimaging and primate neurophysiology.
Conventional methods using surgically implanted head-posts carry risks of infection, discomfort, and signal interference near the cortical surface.
These drawbacks impact data quality and animal welfare, conflicting with the 3Rs principles of refinement.

Purpose of the Study:

To develop and evaluate a completely non-invasive method for head restraint in awake monkeys undergoing fMRI.
To assess the efficacy of a custom-fit plastic head mask in reducing head movements during fMRI scans.
To compare the quality of Blood-Oxygen-Level-Dependent (BOLD) signals obtained with the non-invasive mask versus the conventional head-post method.

Main Methods:

A custom-fit plastic head mask was designed and fabricated for individual monkeys.
The effectiveness of the head mask in suppressing head movements was quantitatively assessed over time.
Retinotopic mapping tasks were performed to acquire BOLD signals in awake monkeys using the head mask.

Main Results:

The non-invasive plastic head mask effectively suppressed head movements in all tested monkeys.
Reliable retinotopic BOLD signals were successfully obtained using the head mask.
Data quality was comparable or superior to that achieved with the conventional head-post method.

Conclusions:

A non-invasive plastic head mask provides an effective and animal-friendly alternative for head restraint in monkey fMRI.
This method simplifies fMRI experiments in primates and enhances data quality.
The technique aligns with ethical considerations for animal research by promoting refinement.