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Fibroblast growth factor 10.

Francesca Rochais1, Robert G Kelly2

  • 1Aix-Marseille Université, MMG, Inserm U1251, Marseille, France.

Differentiation; Research in Biological Diversity
|December 1, 2023
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 10 (FGF10) is crucial for organ development and tissue repair. This signaling molecule impacts multiple systems, and its dysregulation is linked to developmental disorders and cancer.

Keywords:
FGF signalingFibroblast growth factor 10Organogenesis

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Fibroblast growth factor 10 (FGF10) is a key morphoregulatory signaling factor.
  • It primarily acts via FGFR2b on epithelial cells, influencing branching morphogenesis and stem cell fate.
  • FGF10 signaling is vital for the development and homeostasis of numerous organs.

Purpose of the Study:

  • To summarize the multifaceted roles of FGF10 in development, disease, and regenerative medicine.
  • To highlight FGF10's significance in vertebrate organogenesis and tissue repair.
  • To underscore FGF10's potential as a therapeutic target.

Main Methods:

  • Review of genetic loss-of-function analyses in vertebrate models.
  • Analysis of human genetic syndromes associated with FGF10 mutations.
  • Examination of FGF10 expression in cancer and adult tissue homeostasis.

Main Results:

  • FGF10 signaling is essential for limb, lung, digestive, ectodermal, nervous, craniofacial, and cardiac development.
  • FGF10 mutations cause craniofacial anomalies like lacrimal and salivary gland aplasia.
  • Elevated FGF10 expression correlates with poor cancer prognosis and is implicated in tissue repair.

Conclusions:

  • FGF10 is a critical regulator of organ development, homeostasis, and repair.
  • FGF10 signaling is implicated in human genetic disorders and cancer.
  • FGF10 represents a promising target for regenerative medicine strategies.