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Zeolite imidazolate framework-8 in bone regeneration: A systematic review.

Hao Tang1, Yameng Yu1, Xinxin Zhan1

  • 1Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 2, 2023
PubMed
Summary

Zeolite imidazolate framework-8 (ZIF-8) shows promise for bone regeneration by promoting cell growth and bone formation. Appropriate concentrations enhance bone healing, while high doses can be toxic, highlighting the importance of dosage in ZIF-8 applications.

Keywords:
Bone regenerationMetal-organic frameworksStem cellsZeolitic imidazolate framework-8Zinc

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Zeolite imidazolate framework-8 (ZIF-8) is a versatile biomaterial with growing applications in bone regeneration.
  • It offers potential benefits including promoting angiogenesis, drug delivery, and antibacterial activity.

Approach:

  • This systematic review synthesized findings from 39 in vitro and 22 animal studies on ZIF-8 in bone regeneration.
  • Literature search conducted across PubMed, Web of Science, Embase, and Cochrane Library databases.

Key Points:

  • Appropriate concentrations of nano ZIF-8 promote osteogenic differentiation and cell proliferation via Zn2+ release.
  • High ZIF-8 concentrations exhibit cytotoxicity and inhibit osteogenic differentiation.
  • ZIF-8 demonstrates significant vasogenic activity and promotes bone formation in vivo.

Conclusions:

  • Materials incorporating ZIF-8, at suitable concentrations, enhance bone regeneration compared to controls.
  • ZIF-8's multifaceted properties make it a promising candidate for advanced bone regeneration therapies.
  • This review provides insights into ZIF-8's efficacy, mechanisms, and factors influencing its role in bone repair.