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Photocatalytic C-3 Acylation of Indoles Using ICF2SO2Ph as Acyl Fluoride Precursor
Jiarui Liang1, Dandan Xia1, Huanyi Guo1
1Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Pharmacy, Zunyi Medical University, Zunyi 563003, P. R. China.
Abstract:
ICF2SO2Ph represents an important reagent for introducing the CF2SO2Ph functionality into organic scaffolds. Here, we found that ICF2SO2Ph acts as an acyl fluoride precursor, enabling the C-3 acylation of indoles. Under mild visible light photocatalysis, this reaction proceeds smoothly with various nucleophiles. Mechanistic studies confirm that acyl fluoride is generated via cleavage and recombination of ICF2SO2Ph. This work expands the synthetic utility of this reagent and provides a novel photocatalytic strategy for the direct C-3 acylation of indoles.
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