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Updated: Jul 9, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine headache pathophysiology
Anna P Andreou1, Ana D Pereira2
1Headache Research-Wolfson Centre for Age-Related Diseases (CARD), Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Headache Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Abstract:
In both episodic and chronic migraine, headache is the most disabling symptom that requires medical care. The migraine headache is the most well-studied symptom of migraine pathophysiology. The trigeminal system and the central processing of sensory information transmitted by the trigeminal system are of considerable importance in the pathophysiology of migraine headache. Glutamate is the main neurotransmitter that drives activation of the ascending trigeminal and trigeminothalamic pathways. The neuropeptide, calcitonin gene-related peptide (CGRP) that is released by the trigeminal system, plays a crucial role in the neurobiology of headache. Peripheral and central sensitizations associated with trigeminal sensory processing are neurobiologic states that contribute to both the development of headache during a migraine attack and the maintenance of chronic migraine.
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