Related Experiment Video
Updated: Jul 9, 2025
15:04
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
11.0K
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and
Amr Seifelnasr1, Farhad Zare2, Xiuhua April Si3
1Department of Biomedical Engineering, University of Massachusetts, 1 University Ave., Falmouth Hall 302I, Lowell, MA, 01854, USA.
Drug Delivery and Translational Research
|December 3, 2023
Summary
This study developed a new nasal drop delivery method for chronic rhinosinusitis treatment, significantly improving drug delivery to the ostiomeatal complex (OMC) and maxillary sinus with low variability.
Area of Science:
- Otorhinolaryngology
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Chronic and allergic rhinosinusitis affects 12% of the global population.
- Current treatments face challenges due to paranasal sinus inaccessibility and variable drug delivery efficiency.
- Optimizing nasal drug delivery is crucial for effective rhinosinusitis management.
Purpose of the Study:
- To develop and validate a high-efficiency, low-variability protocol for nasal drop delivery to the ostiomeatal complex (OMC) and maxillary sinus.
- To investigate the impact of delivery devices, formulations, and head-chin orientation on drug deposition.
- To overcome anatomical barriers for improved rhinosinusitis treatment.
Main Methods:
- Utilized patient-specific nasal casts for anatomical analysis and visualization of liquid translocation using fluorescent dye.
- Quantified drug delivery to the OMC and maxillary sinus via drop count and mass using a precision scale.
- Systematically evaluated delivery factors including device type, formulation, and head-chin positioning (optimal: 40° head tilt, [specific chin tilt]°).
Main Results:
- Conventional squeeze bottles and soft-mist pumps showed low and highly variable doses to the OMC, with no delivery to the maxillary sinus.
- The proposed method, using a curved nozzle and gravity-driven flow, achieved significant drug delivery to both the OMC and maxillary sinus.
- Established optimal head and chin tilt angles and quantified the required drop count for effective delivery.
Conclusions:
- The developed nasal drop delivery protocol offers a promising solution for enhancing chronic rhinosinusitis treatment by ensuring high efficiency and low variability.
- Nasal anatomy presents both challenges and opportunities for drug delivery, necessitating further research with diverse formulations and larger patient cohorts.
- This approach has the potential to significantly improve therapeutic outcomes for patients suffering from rhinosinusitis.
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