Related Experiment Video
Updated: Jul 9, 2025
07:01
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
Published on: February 7, 2025
409
Pediatric Post-Acute Sequelae of SARS-CoV-2 Infection.
Leonard A Jason1, Madeline Johnson1, Chelsea Torres1
1DePaul University.
Fatigue : Biomedicine, Health & Behavior
|December 4, 2023
Summary
Many Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) symptoms in youth improve over time, but fatigue and post-exertional malaise persist. Youth with PASC generally experience fewer symptoms than those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Area of Science:
- Pediatric Long COVID Research
- Chronic Fatigue Syndrome Studies
- Infectious Disease Sequelae
Background:
- Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) affects youth, with persistent symptoms impacting quality of life.
- Understanding PASC symptom trajectories is crucial for effective management and diagnosis in pediatric populations.
- Comparison with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) aids in differentiating and characterizing these complex conditions.
Purpose of the Study:
- To investigate persistent symptoms in youth diagnosed with PASC.
- To compare the symptomatology of youth with PASC to youth with ME/CFS.
- To identify symptom profiles for tailoring diagnostic criteria and treatment strategies for pediatric PASC.
Main Methods:
- Recruitment of 19 parents of children with PASC via social media for questionnaire completion.
- Assessment of symptoms at two time points: current symptoms and symptoms at initial infection.
- Comparison of PASC cohort with a control group of 19 youth diagnosed with ME/CFS.
Main Results:
- Significant symptom reduction observed in immune, neuroendocrine, pain, and post-exertional malaise (PEM) domains from acute infection to current reporting.
- Persistent high levels of fatigue and symptoms within the sleep and PEM domains were noted.
- Youth with ME/CFS exhibited more severe overall symptomatology compared to youth with PASC, particularly in neurocognitive domains.
Conclusions:
- While many PASC symptoms in youth diminish over time, fatigue and PEM symptoms remain significant.
- Findings provide insights into common symptom profiles for pediatric PASC.
- Results can inform the development of more precise diagnostic criteria and targeted therapeutic interventions for youth with PASC.
Keywords:
COVID-19Long-HaulersPASCPublic Health SignificanceSARS CoV-2 viruschronic fatigue syndromemyalgic encephalomyelitisMore Related Videos
Related Concept Videos
01:17Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
01:21Acute Respiratory Failure-II
241
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
241
01:29Pneumonia II: Pathophysiology
285
The pathophysiology of pneumonia involves the following steps:
285
01:30Pneumonia I: Introduction
245
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
245
01:30Acute Respiratory Failure-III
187
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
187
01:23Acute Respiratory Failure-IV
159
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
159