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Updated: Jul 9, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Case series: cardiac sarcoma.

Michael Killian¹, Timothy Barry¹, Carolyn Larsen¹

¹Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USA.

European Heart Journal. Case Reports

|December 4, 2023

Summary

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Cardiac sarcomas, though rare, are aggressive tumors requiring prompt diagnosis. This study compares primary and secondary cardiac sarcomas, highlighting imaging and management for improved survival.

Area of Science:

Cardiology
Oncology
Radiology

Background:

Cardiac masses present diverse symptoms, often non-specific.
Early identification of cardiac malignancies, like sarcomas, is crucial due to their aggressive nature and poor prognosis.

Observation:

Two cases of dyspnea due to cardiac sarcomas are presented: a primary undifferentiated pleomorphic sarcoma and a secondary round cell myxoid liposarcoma.
Computed Tomography (CT) and echocardiography revealed characteristic locations and morphologies for each sarcoma subtype.

Findings:

Undifferentiated pleomorphic sarcoma is the most common primary cardiac malignancy, often arising in the left atrium.
Round cell myxoid liposarcoma is a rare secondary cardiac malignancy originating from soft tissue metastases.

Keywords:

Cardiac malignancy Cardiac mass Cardiac tumour Case report Case series Liposarcoma Round cell myxoid liposarcoma Sarcoma Undifferentiated pleomorphic sarcoma

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Last Updated: Jul 9, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Implications:

Recognizing cardiac sarcomas is vital for timely intervention, including surgery, radiotherapy, and chemotherapy.
Prompt diagnosis and management are key to maximizing survival rates for patients with cardiac sarcomas.