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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds.

Maryam Ramezani1, Emily Elizabeth Labour1, Jingjing Ji1

  • 1Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.

ACS Applied Materials & Interfaces
|December 4, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed novel antimicrobial shape memory polymers using honey-based phenolic acids to fight bacterial infections and promote wound healing. These smart biomaterials offer tunable properties and controlled shape recovery for enhanced infection treatment.

Keywords:
antimicrobialbiofilmsphenolic acidspolyurethaneshape memory polymer

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Infectious Disease Research

Background:

  • Infection treatment is critical for effective wound healing.
  • Developing advanced materials with antimicrobial properties is essential for combating infections.

Purpose of the Study:

  • To create antimicrobial shape memory polymers (SMPs) using honey-derived phenolic acids (PAs).
  • To investigate chemical and physical incorporation methods for PAs into SMPs.
  • To evaluate the antimicrobial efficacy, mechanical properties, and shape memory behavior of the developed polymers.

Main Methods:

  • Synthesis of segmented shape memory polyurethanes.
  • Incorporation of phenolic acids (PAs) via chemical and physical methods.
  • Assessment of mechanical properties, transition temperatures, and shape memory behavior.
  • Antimicrobial testing against *Staphylococcus aureus* and *Escherichia coli*.
  • Biofilm inhibition assays and molecular dynamics simulations.
  • Evaluation of long-term antimicrobial stability and triggered shape recovery using magnetic particles.

Main Results:

  • Developed cytocompatible SMPs with high transition temperatures (>55 °C).
  • Achieved tunable mechanical and shape memory properties by varying PA incorporation.
  • Demonstrated significant inhibition of bacterial growth (*S. aureus*, *E. coli*) and biofilm formation.
  • Confirmed higher PA interaction with *S. aureus* cell membranes via simulations.
  • Showcased retained antimicrobial activity against *E. coli* for up to 20 days.
  • Proved concept of magnetic particle-triggered shape recovery to disrupt preformed biofilms.

Conclusions:

  • Antimicrobial SMPs incorporating phenolic acids offer a promising platform for infection treatment.
  • Tunable properties and controlled shape recovery enable advanced wound healing applications.
  • This biomaterial platform facilitates user- or environmentally controlled shape change and antimicrobial release.