Single atom nanozymes for bacterial infection therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Infectious Diseases

Background:

• Bacterial infections remain a global health challenge, with rising antimicrobial resistance limiting conventional antibiotic efficacy.
• Novel therapeutic strategies are urgently needed to overcome antibiotic resistance.
• Single-atom nanozymes (SAzymes) are emerging as a promising class of nanocatalytic agents for antibacterial therapy.

Purpose of the Study:

• To provide an overview of recent advancements in the synthesis of metal-based SAzymes.
• To review the current applications of SAzymes in antibacterial therapy.
• To discuss future prospects and challenges for SAzyme-based antibacterial agents.

Main Methods:

• Literature review of synthesis strategies for various metal-based SAzymes.
• Analysis of studies demonstrating the antibacterial efficacy of SAzymes.
• Discussion of structure-activity relationships and mechanisms of action.

Main Results:

• SAzymes exhibit unique advantages, including uniform metal active sites and high atomic utilization efficiency.
• Diverse metal-based SAzymes have been successfully synthesized and applied in treating bacterial infections.
• SAzymes demonstrate potent antibacterial activity through various mechanisms.

Conclusions:

• SAzymes represent a significant advancement in the development of novel antibacterial agents.
• Further research into SAzyme design and clinical translation is warranted.
• SAzymes hold great potential for addressing the challenge of antimicrobial resistance.