NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis

Area of Science:

• Biomaterials Science
• Orthopedic Engineering
• Drug Delivery Systems

Background:

• Traditional magnesium phosphate bone cement (MPC) exhibits limitations such as restricted osteogenesis and rapid drug release.
• These drawbacks hinder the clinical efficacy of MPCs as bone implants.

Purpose of the Study:

• To develop an improved magnesium phosphate bone cement (MPC) with enhanced osteogenic properties and controlled drug release.
• To address the limitations of traditional MPCs for better clinical applications in bone regeneration.

Main Methods:

• Icariin was loaded into mesoporous nano silica containers modified with polydopamine.
• These modified containers and citric acid were incorporated into magnesium phosphate bone cement to create IHP-CA MPCs.

Main Results:

• The developed IHP-CA MPCs demonstrated a prolonged curing time, near-neutral pH, and superior injectability and compressive strength.
• In vitro studies confirmed excellent biocompatibility and significant bone-promoting capabilities of the modified MPCs.

Conclusions:

• The novel IHP-CA MPC formulation offers a promising solution for overcoming the limitations of traditional MPCs.
• These findings provide valuable insights and references for the clinical use of advanced MPCs in bone defect repair and regeneration.