Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Spin–Spin Coupling Constant: Overview

Spin–Spin Coupling Constant: Overview

In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must...

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the...

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...

¹H NMR: Interpreting Distorted and Overlapping Signals

¹H NMR: Interpreting Distorted and Overlapping Signals

Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...

Atomic Nuclei: Nuclear Spin State Overview

Atomic Nuclei: Nuclear Spin State Overview

NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Magnetic Properties of Ge-Doped Fe<sub>3</sub>GaTe<sub>2</sub> van der Waals Ferromagnets.

The journal of physical chemistry letters·2026

Same author

Synergy and Competition of Dual Chirality in the Chirality-Induced Spin Selectivity of Supramolecular Helices.

Journal of the American Chemical Society·2026

Same author

Type-II Dirac Fermions in Monolayer In<sub>2</sub>O: Interplay of Magnetotransport, Spin Hall Effect, and Superconductivity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Robust chirality-induced spin selectivity in topologically chiral molecular knots.

Nature communications·2025

Same author

Stress Relaxation for Lead Iodide Nucleation in Efficient Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Chirality-Induced Majorana Zero Modes and Majorana Polarization.

ACS nano·2024

Search research articles

Related Experiment Video

Updated: Jul 9, 2025

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Published on: June 28, 2018

Spin-Dependent Destructive and Constructive Quantum Interference Associated with Chirality-Induced Spin Selectivity

Song Chen¹, Hua-Hua Fu^1,2

¹School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.

The Journal of Physical Chemistry Letters

|December 4, 2023

Summary

Chirality-induced spin selectivity (CISS) effect was observed in circular helical molecules (CHMs) for the first time. This occurs in closed-loop CHMs with asymmetric lead coupling, revealing spin-dependent quantum interference.

More Related Videos

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Related Experiment Videos

Last Updated: Jul 9, 2025

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Published on: June 28, 2018

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Area of Science:

Condensed Matter Physics
Molecular Electronics
Quantum Chemistry

Background:

The Chirality-induced spin selectivity (CISS) effect is well-studied in linear helical molecules.
Exploration of the CISS effect in circular helical molecules (CHMs) remains limited.

Purpose of the Study:

To investigate the CISS effect in single circular helical molecules.
To identify the conditions necessary for observing the CISS effect in CHMs.
To explore associated quantum interference phenomena.

Main Methods:

Construction of single CHMs with inherent chirality-induced spin-orbit coupling (SOC).
Integration of CHMs with two nonmagnetic leads.
Theoretical modeling and simulation of electronic transport properties.

Main Results:

The CISS effect was successfully achieved in CHMs for the first time.
Observation requires CHMs to form a closed loop with asymmetric coupling to the leads.
Spin-dependent destructive and constructive quantum interference (QI) phenomena were identified, including phase transitions.

Conclusions:

This study establishes the conditions for CISS effect in CHMs.
The findings reveal novel spin-dependent quantum interference in circular helical systems.
This work opens new avenues for understanding CISS physics in helical molecular systems.