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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Jul 9, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Targeting Senescent Cells as Therapy for CKD.

Katie J Mylonas1, David A Ferenbach

  • 1Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.

Kidney360
|December 5, 2023
PubMed
Summary

Senescent cells drive kidney disease progression. Targeting these cells with senolytics may improve kidney repair and function, offering new therapeutic avenues for chronic kidney disease patients.

Area of Science:

  • Nephrology and Gerontology
  • Cellular Biology and Aging

Background:

  • Senescent cells, characterized by permanent cell cycle arrest, accumulate in aging and injured kidneys, including failing transplants.
  • These cells secrete pro-inflammatory and pro-fibrotic factors, contributing to kidney disease progression and dysfunction.
  • Chronic accumulation of senescent cells links acute kidney injury to progressive fibrosis and mortality in chronic kidney disease (CKD).

Approach:

  • Review of current protocols for identifying senescent cells in vitro and in vivo.
  • Discussion of mechanisms of action for first-generation senolytic (e.g., ABT-263) and senomorphic (e.g., metformin) agents.
  • Exploration of emerging technologies, including nanocarriers for targeted senolytic delivery and immune-based elimination strategies.

Key Points:

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  • Senescent cells play a causative role in the progression of kidney disease.
  • Targeting senescent cells can potentially enhance renal regeneration, reduce fibrosis, and improve functional recovery post-injury.
  • Research is focused on understanding the link between senescent cells and CKD progression, dysfunction, and mortality.

    • Conclusions:

    • Developing targeted senolytic compounds and non-invasive monitoring tools is crucial for clinical translation.
    • Senolytic treatments hold promise for moving from preclinical research to effective bedside therapies for kidney diseases.
    • Understanding senescence in kidney homeostasis and disease paves the way for novel therapeutic interventions.