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Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review

Weixing Xu1,2, Hua Liu1,3

  • 1School of Graduate, Dalian Medical University, Dalian, China.

Medicine
|December 5, 2023
PubMed

Insights

Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a dual role in eye cell apoptosis. Early CaMKII elevation promotes apoptosis, but its overexpression can combat it.

Area of Science:

  • Ophthalmology and molecular biology
  • Cellular biology and disease mechanisms

Background:

  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) is crucial for cellular processes, including apoptosis.
  • Previous research on CaMKII's role in eye cell apoptosis has yielded conflicting results.

Approach:

  • This review synthesizes existing literature on CaMKII's effects on eye cell apoptosis.
  • It examines both the pro-apoptotic and anti-apoptotic roles of CaMKII.

Key Points:

  • Early elevation of CaMKII activity appears to promote eye cell apoptosis.
  • Overexpression of CaMKII, achieved through transfection or specific drugs, can protect against apoptosis.

Conclusions:

  • CaMKII has a complex, context-dependent role in eye cell apoptosis.
  • Understanding these effects is vital for developing therapeutic strategies for eye diseases.

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