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Updated: Jul 9, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Design and Synthesis of Bicyclo[4.3.0]nonene Nucleoside Analogues
Stephan Scheeff1, Yan Wang2,3, Mao-Yun Lyu1
1School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin , Hong Kong.
Abstract:
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, we present the design and synthesis of novel nucleoside analogues with a carbobicyclic core, which mimics the conformation of natural ribonucleosides. Employing a divergent synthetic route featuring an intermolecular Diels-Alder reaction, we successfully synthesized carbobicyclic nucleoside analogues with high antiviral efficacy against respiratory syncytial virus.
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