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Updated: Jul 9, 2025

Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps
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Characterization of an N-Allylglyoxylamide-Based Bioorthogonal Nitrone Trap

Daniel Lee1, Simon Latour2,3, Michael Emblem1

  • 1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

Bioconjugate Chemistry
|December 5, 2023
PubMed
Summary

This study introduces a new bioorthogonal reaction combining nitrones and aldehydes to form stable bicyclic isoxazolidines. This efficient reaction works in cell lysates and on cell surfaces, expanding bioorthogonal chemistry tools.

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