Related Experiment Video

Updated: Aug 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K

Post-implantation CMR imaging to study biventricular pacing effects on the right ventricle in left bundle branch

Luuk H G A Hopman1, Alwin Zweerink1, Mariëlle C van de Veerdonk1

  • 1Department of Cardiology, Amsterdam UMC, Amsterdam, The Netherlands.

Pacing and Clinical Electrophysiology : PACE
|December 6, 2023
PubMed

Insights

Cardiac resynchronization therapy (CRT) did not improve right ventricular (RV) function in heart failure patients. Stopping CRT temporarily worsened RV function, suggesting RV pacing during CRT may lead to adverse RV remodeling.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is a standard treatment for specific heart failure patients.
  • The effect of CRT on right ventricular (RV) function is not well understood.
  • Left ventricular dysfunction and left bundle branch block are common indications for CRT.

Purpose of the Study:

  • To investigate the impact of CRT on RV volumes and function.
  • To assess the immediate effects of CRT withdrawal on RV function.
  • To explore potential RV remodeling associated with RV pacing during CRT.

Main Methods:

  • Utilized cardiac magnetic resonance imaging (CMR) to assess RV function.
  • Monitored RV volumes and function in patients undergoing CRT.
  • Evaluated RV function during periods of CRT-on and CRT-off.

Main Results:

  • CRT did not lead to significant improvements in RV volumes or function.
  • Temporary cessation of CRT resulted in an immediate negative impact on RV function.
  • Findings suggest a potential for unfavorable RV remodeling due to RV pacing within CRT.

Conclusions:

  • CRT may not benefit RV function in heart failure patients with left ventricular dysfunction and LBBB.
  • RV pacing during CRT could be associated with detrimental RV remodeling.
  • Further research is needed to optimize CRT strategies for RV health.

Keywords:
cardiac MRIcardiac resynchronization therapyright ventricle

More Related Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

633

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...