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Molecular Recognition with Macrocyclic Receptors for Application in Precision Medicine
Yu-Chen Pan1, Jia-Hong Tian1, Dong-Sheng Guo1
1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.
Macrocyclic receptors offer stable, tunable alternatives for molecular recognition. New strategies enhance binding affinity for applications in precision medicine, including diagnostics and drug delivery.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Macrocyclic receptors offer enhanced stability and reproducibility over natural recognition systems.
- Their tunable cavities enable host-guest interactions, influencing guest physiochemical properties.
- Current limitations include insufficient binding affinity and selectivity for bioactive molecules in medical applications.
Purpose of the Study:
- To develop innovative strategies for enhancing macrocyclic receptor binding affinity and selectivity towards bioactive molecules.
- To explore the application of these advanced macrocyclic receptors in precision medicine.
Main Methods:
- Longitudinal cavity extension to increase hydrophobic effects and interaction area.
- Coassembled heteromultivalent recognition using macrocyclic amphiphiles for complexation.
- Application of developed systems in biosensing, bioimaging, drug delivery, and therapeutics.
Main Results:
- Achieved specific and strong binding of macrocyclic receptors to biomarkers, drugs, and disease-related peptides/proteins.
- Demonstrated successful application in biosensing, bioimaging, targeted drug delivery, and therapeutic interventions.
- Overcame limitations of low diagnosis accuracy and off-target effects.
Conclusions:
- The developed strategies significantly improve macrocyclic receptor performance for recognizing bioactive molecules.
- These advanced receptors hold substantial potential for advancing precision medicine through improved diagnostics and therapeutics.
- Further research can expand supramolecular chemistry applications and open new avenues in personalized healthcare.
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