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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Related Experiment Video

Updated: Jul 9, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Exploring the Autoimmune Pathogenesis in Severe Asthma.

Liping Liu1, Fengying Tian1, Yuemei Sun1

  • 1Department of Allergy, Yantai Yuhuangding Hospital, Yantai, China.

International Archives of Allergy and Immunology
|December 7, 2023
PubMed
Summary
This summary is machine-generated.

Severe asthma patients show higher IL-17 levels and positive autologous serum skin tests (ASST), suggesting a potential autoimmune link. This indicates IL-35 may have a reduced role in controlling inflammation in severe cases.

Keywords:
ASSTIL-17IL-35PathogenesisSevere asthma

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Pathogenesis of Asthma

Background:

  • Severe asthma exhibits poor treatment response and control, necessitating research into novel pathogenetic mechanisms.
  • Interleukin-35 (IL-35) may protect against autoimmune diseases by inhibiting pro-inflammatory Interleukin-17 (IL-17).
  • The autologous serum skin test (ASST) is a validated screening tool for autoimmune antibodies.

Purpose of the Study:

  • To investigate the role of IL-35 and IL-17 in severe asthma.
  • To compare ASST positivity, exhaled nitric oxide (FeNO), and atopic status between mild-to-moderate and severe asthma patients.
  • To explore potential autoimmune pathogenesis in severe asthma.

Main Methods:

  • Enrolled patients with mild-to-moderate and severe asthma.
  • Analyzed clinical data including smoking history, family history, allergic rhinitis, allergen-specific IgE, and FeNO.
  • Measured serum IL-35 and IL-17 levels using ELISA and assessed ASST results.

Main Results:

  • Severe asthma patients had higher rates of smoking history, family history, and positive ASST compared to mild-to-moderate asthma patients.
  • Serum IL-17 levels were significantly elevated in severe asthma, while IL-35 levels showed no significant difference.
  • Positive ASST results correlated with an increased risk of severe asthma (OR=5.277), whereas allergen positivity decreased this risk (OR=0.123).

Conclusions:

  • Elevated IL-17 and high ASST positivity in severe asthma suggest a potential autoimmune component.
  • IL-35 appears to have a diminished inhibitory effect on IL-17 in severe asthma.
  • These findings highlight the need to consider autoimmune mechanisms in the pathogenesis of severe asthma.