Related Experiment Video
Updated: Jul 9, 2025
10:21
Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions
Published on: October 5, 2019
8.4K
[The Redox-Catalytic Properties of Cobalamins]
Yu V Shatalin1,2, V S Shubina1, M E Solovieva1
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast', 142290 Russia.
Molekuliarnaia Biologiia
|December 8, 2023
Summary
Vitamin B12 (cobalamin) has anti-inflammatory and antioxidant benefits but can become prooxidant with reducing agents like vitamin C. Understanding these dual roles is key for safe therapeutic use.
Area of Science:
- Biochemistry
- Nutrition Science
- Medical Research
Background:
- Vitamin B12 (cobalamin) is vital for bodily functions and disease therapy.
- It exhibits anti-inflammatory and antioxidant properties beneficial for disease prevention.
- However, combinations with reducing agents like ascorbate and thiols can induce prooxidant activity.
Approach:
- This review synthesizes information on vitamin B12's role in inflammatory and oxidative stress-related diseases.
- It examines the effects of vitamin B12, alone and with reducing agents, on oxidative stress.
- Mechanisms of prooxidant actions, considering different vitamin B12 forms (hydroxocobalamin, cyanocobalamin), are discussed.
Key Points:
- Vitamin B12 possesses both beneficial antioxidant/anti-inflammatory and potentially harmful prooxidant properties.
- The prooxidant effect is observed when vitamin B12 is combined with reducing agents like vitamin C and thiols.
- The specific form of vitamin B12 influences its prooxidant activity.
Conclusions:
- Understanding the dual nature of vitamin B12 is crucial for its therapeutic application.
- Further research into the mechanisms of its prooxidant action is needed.
- This knowledge will guide strategies for safe and effective vitamin B12 administration in clinical settings.
![Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55858.jpg&w=3840&q=50)
Related Concept Videos
03:02Colors and Magnetism
11.7K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
11.7K
01:24Redox Reactions
55.7K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
55.7K
01:17Oxidation of Phenols to Quinones
3.1K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.1K
01:23Redox Equilibria: Overview
564
A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
564
01:26Redox Titration: Other Oxidizing and Reducing Agents
294
Besides iodine, other oxidizing or reducing agents can serve as titrants in redox titrations. Common oxidizing titrants include KMnO4, cerium(IV), and K2Cr2O7. The choice of oxidizing titrants depends on factors like stability, cost, analyte strength, and reaction rate between the analyte and titrant. KMnO4 is a strong oxidizing titrant that reduces from Mn(VII) to Mn(II) in a highly acidic solution, simultaneously oxidizing the analyte to a higher oxidation state. In this case, KMnO4 acts as a...
294
03:11Oxidation-Reduction Reactions
65.0K
Oxidation–Reduction Reactions
65.0K