Related Experiment Video
Updated: Jul 9, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
Published on: October 11, 2018
Sleep in pediatric neuromuscular disorders.
John E Pascoe1, Alexander Zygmunt2, Zarmina Ehsan3
1Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Sleep disordered breathing (SDB) affects many children with neuromuscular disorders (NMD). Early diagnosis and treatment, often with ventilation, are crucial to prevent serious health issues.
Area of Science:
- Pediatric Pulmonology
- Neurology
- Sleep Medicine
Background:
- Sleep disordered breathing (SDB) is common in children with neuromuscular disorders (NMD).
- Respiratory muscle weakness, altered respiratory drive, and scoliosis exacerbate sleep stress in this population.
- Untreated SDB can lead to cardiovascular, metabolic, and neurocognitive complications.
Conclusions:
- Clinicians should maintain a high suspicion for SDB in children with NMD.
- Individualized assessment is necessary due to varied muscle group involvement.
- Prompt diagnosis and management of SDB are vital for improving outcomes in pediatric NMD.
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Narcolepsy
Skeletal Muscle Relaxants: Therapeutic Uses
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...

