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Adjuvant AS01 activates human monocytes for costimulation and systemic inflammation

Carson L Smith1, Brian Richardson2, Michael Rubsamen3

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Vaccine
|December 8, 2023
PubMed
Summary

The adjuvant AS01 strongly activates human monocytes, enhancing immune responses even in older adults. This finding is crucial for understanding vaccine efficacy and improving responses in the elderly.

Keywords:
AS01AdjuvantCostimulationImmunosenescenceMonocytes

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