Measurement of trigonal sensitivity as a test of bladder function

Area of Science:

• Urology
• Neuroscience
• Physiology

Background:

• The urge to urinate is triggered by pressure receptors in the bladder and urethra.
• Understanding these sensory mechanisms is crucial for diagnosing and managing voiding dysfunction.

Purpose of the Study:

• To develop and validate a method for measuring pressure perception thresholds in the bladder and posterior urethra.
• To investigate how these thresholds differ in individuals with normal voiding versus those with various urinary disorders.

Main Methods:

• A balloon catheter was used to apply controlled force to the bladder base and posterior urethra.
• The force required to elicit the urge to void was recorded in different patient groups and healthy individuals.
• Lidocaine was applied to assess its effect on sensory perception.

Main Results:

• Normal voiding perception occurred at 245 +/- 47 gm force.
• Patients with irritative symptoms perceived the urge at a significantly lower force (132 +/- 50 gm).
• Post-prostatectomy patients required more force (344-469 gm), and some chronic retention patients had reduced perception (526 +/- 32 gm).
• Lidocaine reduced sensitivity by 210 +/- 114 gm.

Conclusions:

• Pressure-sensitive receptors in the bladder and urethra play a key role in micturition.
• This method allows for quantitative assessment of these sensory receptors.
• Findings suggest potential for new therapeutic protocols targeting these receptors for voiding disorders.