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Updated: Jul 9, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration
Aleksandra Żórawik1, Wojciech Hajdusianek1, Iwona Markiewicz-Górka1
1Department of Population Health, Division of Environmental Health and Occupational Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wroclaw, Poland.
Insights
Higher cardiovascular disease risk factors correlate with lower blood renalase concentration (BRC). Obesity, smoking, and lack of physical activity were key factors linked to reduced BRC in patients.
Area of Science:
- Biochemistry
- Cardiology
- Metabolic Diseases
Background:
- Cardiovascular diseases (CVDs) pose a significant global health challenge.
- Lifestyle-related risk factors, such as tobacco use, are crucial contributors to CVD.
- Renalase, a flavoprotein, is implicated in cardiometabolic disease progression.
Purpose of the Study:
- To investigate the relationship between cardiovascular disease risk factors (CVRFs) and blood renalase concentration (BRC).
Main Methods:
- Assessed CVRFs using the AHA Life 7 scale in 96 hospitalized patients.
- Measured BRC using the E3109Hu ELISA kit.
- Employed regression and ROC analysis to identify associations.
Main Results:
- Higher BRC was observed in individuals with fewer CVRFs (p < 0.05).
- A negative correlation (r = -0.41) was found between BRC and the number of CVRFs.
- Obesity, smoking, and lack of physical activity (LoPE) were independently linked to lower BRC.
Conclusions:
- Patients with a greater number of CVRFs exhibit lower BRC.
- Obesity, smoking, and LoPE are significant CVRFs associated with decreased BRC.
Abstract:
Cardiovascular diseases (CVDs) are one of the biggest health challenges facing health systems around the world. There are certain risk factors (CVRFs) that contribute to CVD. Risk factors associated with lifestyle such as tobacco consumption are particularly essential. Renalase is a recently discovered flavoprotein that may be involved in the progression of cardiometabolic diseases. The aim of the study was to investigate the relation between CVRFs and blood renalase concentration (BRC). The study group consisted of 96 people (51% women) who were hospitalized in the internal medicine department. CVRFs were measured using the AHA Life 7 scale. The E3109Hu ELISA kit was used to assess BRC. We found higher BRC in groups with a lower number of CVRFs (p < 0.05). We found a negative correlation between BRC and the number of CVRFs (r = -0.41). With the regression analysis, obesity, smoking, and a lack of physical activity (LoPE) were independently associated with lower blood renalase concentration. ROC analysis indicated the highest accuracy of BRC < 38.98 ng/mL in patients with ≥5 CVRFs. In conclusion, patients with a higher number of CVRFs had lower BRCs. The CVRFs particularly associated with a lower BRC were obesity, smoking, and LoPE.
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