Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

100
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
100
Anatomy of the Intestines01:23

Anatomy of the Intestines

72.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Microbiota and Autism Spectrum Disorders: Neurodevelopmental, Behavioral, and Gastrointestinal Interactions.

Nutrients·2025
Same author

Oral Microbiota Composition and Its Association with Gastrointestinal and Developmental Abnormalities in Children with Autism Spectrum Disorder.

Microorganisms·2025
Same author

The Impact of Acute EBV Infection on Changes in the Serum Proteome in Children-A Pilot Study.

Pathogens (Basel, Switzerland)·2024
Same author

Anti-SARS-CoV-2 Antibodies Level and COVID-19 Vaccine Boosters among Healthcare Workers with the Highest SARS-CoV-2 Infection Risk-Follow Up Study.

Vaccines·2024
Same author

Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children.

Life (Basel, Switzerland)·2023
Same author

The Coexistence of Antibodies to Neuronal Cell and Synaptic Receptor Proteins, Gangliosides and Selected Neurotropic Pathogens in Neurologic Disorders in Children.

Diagnostics (Basel, Switzerland)·2023

Related Experiment Video

Updated: Jul 9, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K

Microbiota in Autism Spectrum Disorder: A Systematic Review.

Zuzanna Lewandowska-Pietruszka1, Magdalena Figlerowicz1, Katarzyna Mazur-Melewska1

  • 1Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, 60-572 Poznan, Poland.

International Journal of Molecular Sciences
|December 9, 2023
PubMed
Summary

Children with autism spectrum disorder (ASD) show gut bacteria differences, with potential improvements seen through probiotics and microbiota transfer therapy, offering new avenues for the gut-brain axis.

Keywords:
autism spectrum disorderbehaviorfunctional gastrointestinal disordermicrobiotasystematic review

More Related Videos

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.0K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.1K

Related Experiment Videos

Last Updated: Jul 9, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.0K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.1K

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Autism spectrum disorder (ASD) is a neurodevelopmental condition with core symptoms including social interaction and communication difficulties.
  • Many children with ASD experience gastrointestinal (GI) disorders, which can significantly impact their quality of life.
  • Emerging research suggests a link between gut microbiota dysbiosis and both core ASD symptoms and GI issues.

Approach:

  • This review systematically analyzed forty-four studies, including meta-analyses, reviews, and original research, focusing on the gut microbiota composition in children with ASD.
  • The analysis examined specific bacterial phyla alterations and the Bacteroidetes to Firmicutes ratio in ASD individuals compared to controls.
  • Interventions targeting gut microbiota modulation, such as probiotics, prebiotics, and microbiota transfer therapy (MTT), were assessed for their efficacy.

Key Points:

  • ASD children exhibit altered gut microbiota profiles, with trends showing increased Firmicutes and Pseudomonadota and decreased Bacteroidetes.
  • A lower Bacteroidetes to Firmicutes ratio in ASD is associated with behavioral and GI abnormalities.
  • Probiotic interventions using Lactobacillus, Bifidobacterium, and Streptococcus strains demonstrated potential in alleviating ASD-related behavioral and GI symptoms.

Conclusions:

  • The gut microbiota plays a significant role in the gut-brain axis, influencing both core ASD symptoms and associated GI disorders.
  • Microbiota transfer therapy (MTT) shows promise for lasting benefits, while prebiotics require further investigation for conclusive efficacy.
  • Standardized, comprehensive research is crucial to overcome study heterogeneity and methodological variations, paving the way for effective gut-targeted therapies for ASD.