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Decelerated Epigenetic Aging in Long Livers.

Zulfiya G Guvatova1,2, Anastasiya A Kobelyatskaya2, Elena A Pudova2

  • 1Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow 129226, Russia.

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|December 9, 2023
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Summary
This summary is machine-generated.

Epigenetic aging is slower in long-lived individuals, with their epigenetic age appearing 21 years younger than their chronological age. Frailty and sex did not significantly impact this epigenetic age difference in centenarians.

Keywords:
DNA methylationagingepigenetic clocklong liverspyrosequencing

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Area of Science:

  • Gerontology
  • Epigenetics
  • Genomics

Background:

  • Epigenetic aging is a key area in aging research.
  • Long-lived individuals represent successful aging and are subjects of global study.
  • Understanding epigenetic markers in centenarians can reveal mechanisms of longevity.

Purpose of the Study:

  • To estimate epigenetic age in long-lived individuals (over 90 years old).
  • To compare epigenetic age between healthy and frail long-livers.
  • To investigate potential sex differences in epigenetic aging among centenarians.

Main Methods:

  • Utilized Bekaert's blood-based age prediction model.
  • Assessed DNA methylation status at 4 specific CpG sites (ASPA, PDE4C, ELOVL2, EDARADD) via pyrosequencing.
  • Employed the Frailty Index for frailty assessment in long-livers.

Main Results:

  • Long-livers exhibited an epigenetic age significantly lower (by ~21 years) than their chronological age.
  • No significant difference in delta age was found between healthy and frail long-livers.
  • No significant sex differences in epigenetic age were detected in either long-livers or controls.

Conclusions:

  • Epigenetic aging appears to be slower in centenarians, suggesting delayed biological aging.
  • Frailty status and sex may not be primary determinants of epigenetic age in this long-lived cohort.
  • Further research on centenarian epigenetics is crucial for understanding aging processes.