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Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms
Siqi Liu1, Yufeng He1, Yali Zhang1
1Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Gut Microbes
|December 11, 2023
Summary
The aging population faces rising cardiovascular disease. Gut microbiota and its metabolites offer new therapeutic targets for preventing and treating these age-related conditions.
Area of Science:
- Cardiology
- Microbiology
- Gerontology
Background:
- Global populations are aging, leading to an increase in age-related cardiovascular diseases.
- High readmission and mortality rates persist despite managing cardiovascular risk factors.
Purpose of the Study:
- To review the intricate relationship between gut microbiota and age-related cardiovascular diseases.
- To explore the potential of gut microbiota as a novel therapeutic target.
Main Methods:
- Literature review of recent in-depth studies.
- Analysis of molecular pathways influenced by gut microbiota and its metabolites.
Main Results:
- Gut microbiota composition and metabolites (TMAO, BAs, SCFAs) significantly impact cardiovascular disease development.
- These factors influence cardiovascular health through diverse molecular mechanisms.
Conclusions:
- The gut microbiota presents a promising new frontier for the prevention and treatment of age-related cardiovascular diseases.
- Targeting gut microbiota offers a novel therapeutic strategy for cardiovascular health in aging populations.
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