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Updated: Jul 8, 2025
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Analysis of risk factors for changes of left ventricular function indexes in Chinese patients with gout by
Wantai Dang1, Danling Luo2, Jing Hu2
1Department of Rheumatology and Immunology, Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Insights
Elevated urea and fasting plasma glucose (FPG) are linked to subclinical left ventricular (LV) dysfunction in gout patients. This finding aids early heart disease diagnosis and treatment in this population.
Area of Science:
- Cardiology
- Rheumatology
- Medical Diagnostics
Background:
- Limited echocardiographic data exists on the association between left ventricular (LV) function and gout.
- Cardiovascular disease is a significant concern in patients with gout.
- Early detection of cardiac involvement in gout patients is crucial for timely intervention.
Purpose of the Study:
- To investigate the relationship between echocardiographic parameters, assessed via 2D speckle tracking, and clinical indicators in gout patients.
- To establish a clinical foundation for the early diagnosis and management of cardiovascular disease in individuals with gout.
Main Methods:
- Gout patients were recruited from outpatient and inpatient departments between November 2019 and December 2020.
- Spearman correlation analysis was used to determine correlations between laboratory indicators and echocardiographic parameters.
- Multivariate logistic regression analysis was employed to identify independent risk factors.
Main Results:
- Fasting plasma glucose (FPG) was identified as a risk factor for decreased global longitudinal strain (GLS).
- Elevated urea levels were associated with reduced global circumferential strain (GCS), increased E/Em ratio, left ventricular hypertrophy (LVH), and enlarged left atrial volume index (LAVI).
- Age and hypertension were also found to be risk factors for an increased E/Em ratio.
Conclusions:
- Increased urea and FPG levels are significant risk factors for subclinical left ventricular myocardial dysfunction in patients with gout.
- These findings support the potential for using echocardiographic parameters and specific biomarkers for early detection of cardiac complications in gout.
- The study provides a theoretical basis for optimizing the early diagnosis and treatment strategies for cardiovascular disease in gout patients.
Abstract:
Background: Echocardiographic data investigating the association between left ventricular (LV) function and gout is still limited. Purpose: To analyze the association of echocardiographic parameters based on two-dimentional speckle tracking analysis with clinically related indicators in patients with gout, and to provide a clinical basis for the early diagnosis and treatment of cardiovascular disease in patients with gout. Methods: This study collected gout patients who visited the outpatient and inpatient departments of the first affiliated hospital of chengdu medical college from November 2019 to December 2020. Spearman correlation test was performed to analyze the correlation coefficients between the laboratorial indicators with echocardiographic parameters. And the logistic regression analysis was performed to evaluate the independent effects. Results: The results of multivariate logistic regression showed that fasting plasma glucose (FPG) was a risk factor for the decrease in absolute value of global longitudinal strain [GLS (OR = 2.34; 95% CI, 1.01-5.39; p = 0.04)], Urea was a risk factor for absolute reduction in GCS (OR = 1.40; 95% CI, 1.07-1.85; p = 0.02), age (OR = 1.09, 95% CI, 1.04-1.16; p = 0.001), and hypertension (OR = 8.35; 95% CI, 1.83-38.02; p = 0.006) were risk factors for increased E/Em. High urea levels were significantly related with high risks of LVH (OR = 1.59, 95% CI, 1.04-2.43; p = 0.03) and enlargement of LAVI (OR = 1.68, 95% CI, 1.01-2.80; p = 0.04). Conclusion: Our study found that elevated urea and FPG were risk factors for subclinical LV myocardial dysfunction in patients with gout, which might provide a theoretical basis for the early diagnosis and treatment of heart disease in clinical practice.
