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Updated: Jul 8, 2025
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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
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Circular RNAs in glioma: Molecular functions and pathological implications
Cheng Tang1, Xinyi He1, Lintao Jia1
1Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Non-Coding RNA Research
|December 11, 2023
Summary
Circular RNAs (circRNAs), stable non-coding RNAs, are increasingly linked to various diseases, particularly glioma. Their altered expression suggests potential as diagnostic and therapeutic biomarkers for brain tumors.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are a distinct class of stable, conserved non-coding RNAs with a unique ring structure.
- Their biogenesis, properties, and regulatory roles (miRNA sponge, translation, exosomal interaction) are under active investigation.
- Aberrant circRNA expression is observed in numerous diseases, notably cancer, necessitating novel diagnostic and therapeutic strategies.
Purpose of the Study:
- To review current knowledge on circRNA biogenesis, translation, and interactions in disease.
- To focus on the specific roles of circRNAs in glioma progression, including tumorigenesis, proliferation, invasion, and metastasis.
- To highlight the potential of circRNAs as diagnostic, prognostic, and therapeutic biomarkers for glioma.
Main Methods:
- Literature review of studies on circRNA biogenesis, function, and disease association.
- Analysis of research focusing on circRNA alterations in glioma.
- Synthesis of findings regarding circRNA roles in glioma pathogenesis and clinical utility.
Main Results:
- CircRNAs are systematically altered in glioma, playing critical roles in tumor development.
- Their unique properties make them promising candidates for biomarkers in glioma diagnosis and prognosis.
- CircRNAs represent potential therapeutic targets for glioma intervention.
Conclusions:
- Circular RNAs are significantly implicated in glioma progression and hold substantial potential as biomarkers.
- Further exploration of circRNAs is crucial for advancing glioma diagnosis, treatment, and patient outcomes.
- CircRNAs offer a promising avenue for developing novel therapeutic strategies against glioma.
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