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Differences in structural connectome organization across sleep quality.

Yoonsun Yang1, Bo-Yong Park2,3,4

  • 1Artificial Intelligence Convergence Research Center, Inha University, Incheon, Republic of Korea.

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Summary
This summary is machine-generated.

Poor sleep quality is linked to altered brain structure. This study reveals changes in the whole-brain structural connectome, particularly in unimodal association and limbic regions, associated with negative experiences like pain.

Keywords:
Cognitive decodingDimensionality reductionMagnetic resonance imagingSleep qualityStructural connectivity

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Area of Science:

  • Neuroimaging
  • Brain Connectomics
  • Sleep Science

Background:

  • Sleep quality significantly impacts overall health.
  • Previous research shows altered brain morphology and function in poor sleepers.
  • The effect of sleep quality on whole-brain structural connectivity remains underexplored.

Purpose of the Study:

  • To investigate the association between sleep quality and whole-brain structural connectome organization.
  • To identify specific brain regions and networks affected by sleep quality variations.

Main Methods:

  • Utilized diffusion MRI tractography to map structural connectivity.
  • Applied dimensionality reduction techniques to analyze low-dimensional eigenvectors of the structural connectome.
  • Assessed associations between these brain network measures and subjective sleep quality.

Main Results:

  • Found significant associations between sleep quality and structural organization in unimodal association and limbic regions.
  • Meta-analytic cognitive decoding linked these alterations to negative concepts, including nociception and pain.
  • Identified specific patterns of whole-brain structural changes related to sleep quality.

Conclusions:

  • Sleep quality is associated with alterations in the whole-brain structural connectome.
  • Findings suggest a neurobiological link between poor sleep, brain structure, and negative sensory experiences.
  • Provides novel insights into the brain basis of sleep quality.