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Compact Electrochromic Optical Recording of Bioelectric Potentials.
Kenneth Nakasone1, Chris Zavik1, Erica Liu2,3
1Department of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Arxiv
|December 11, 2023
Summary
We developed a Compact Electrochromic Optical Recording (CECORE) system, simplifying complex setups for label-free cell electrical signal detection. This portable device offers high sensitivity for studying cardiomyocyte action potentials.
Area of Science:
- Biophysics
- Optical Engineering
- Cellular Electrophysiology
Background:
- Electrochromic optical recording (ECORE) offers label-free detection of cellular electrical signals with high signal-to-noise ratio.
- Traditional ECORE systems are large, complex, and difficult to transport, limiting scalability and field applications.
Conclusions:
- The CECORE apparatus provides a simplified, portable, and sensitive solution for label-free electrophysiological recordings.
- This technology facilitates easier transport and large-scale studies of cellular electrical activity.
- Potential for further improvement by filtering power-line interference to approach the shot noise limit.
