Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts
Zer Vue1, Peter T Ajayi2, Kit Neikirk1
1Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Biorxiv : the Preprint Server for Biology
|December 11, 2023
Abstract:
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.
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