[Preoperative thermoradio- and thermochemotherapy of breast cancer]

Thermoradio- and thermochemotherapy were employed for the treatment of 85 patients with stage II-III breast cancer. 80 patients of the control group were given either radio- or chemotherapy. In 3 hrs large fractions of irradiation (a single focal dose of 6 Gy and total focal dose of 18 Gy) of the breast, axillary and subclavicular regions or chemotherapy (i.v. injection of vincristine, 5-FU, cyclophosphamide and methotrexate) were followed by local MWF-hyperthermia (915 MHz) to 43 degrees C tumor temperature for 60 min. 3-day treatment was followed by mastectomy on the 4th day. Preoperative thermoradio- and thermochemotherapy made it possible to achieve pronounced pathomorphosis of breast cancer in most of the patients during 3 days, to lower tumor malignancy and the danger of intraoperative metastases.