[Metastasis of Lewis carcinoma during local UHF hyperthermia]

The paper is concerned with the results of a study of the relation of a metastatic spreading of mouse Lewis carcinoma to temperature distribution in the area of a tumor and healthy tissue damage. It was shown that a significant metastatic spreading inhibition was observed in selective MWF-hyperthermia (43-46 degrees C, 30 min). In the absence of a selective hyperthermal exposure when both tumors and healthy tissues were damaged (at the same thermal dose), there was a tendency to metastatic spreading enhancement. A considerable metastatic growth was noted after tumor-affected limb amputation without hyperthermal exposure.