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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications.

Yuqi Zhao1, Zhi Zheng1, Cui-Yun Yu1

  • 1Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & School of Pharmaceutical Science, Hengyang Medical School, University of South China, 28 W Changsheng Road, Hengyang 421001, Hunan, China. zhengzhi@usc.edu.cn.

Journal of Materials Chemistry. B
|December 11, 2023
PubMed
Summary
This summary is machine-generated.

Cyclodextrin-based supramolecular hydrogels offer versatile drug delivery solutions. This review details their design, properties, and biomedical applications, highlighting future prospects for clinical translation.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Cyclodextrin (CD)-based supramolecular hydrogels are advanced polymer networks.
  • They exhibit rapid formation of reversible 3D porous structures via cross-linking.
  • These hydrogels show significant promise for drug delivery applications.

Purpose of the Study:

  • To provide a comprehensive overview of CD-based supramolecular hydrogels.
  • To detail their structure, mechanical property modulation, and drug delivery capabilities.
  • To explore their applications in biomedical fields from a cross-linking perspective.

Main Methods:

  • Systematic review of existing literature on CD-based supramolecular hydrogels.
  • Analysis of cross-linking strategies and their impact on hydrogel properties.
  • Evaluation of drug loading, release mechanisms, and biomedical applications.

Main Results:

  • Detailed description of CD-based supramolecular hydrogel design and mechanical property regulation.
  • Exploration of various drug loading and release modes.
  • Summary of applications in oncology, wound dressing, bone repair, and myocardial tissue engineering.

Conclusions:

  • CD-based supramolecular hydrogels present a promising platform for biomedical applications.
  • Further research into their challenges and prospects can accelerate clinical translation.
  • This review offers insights for developing advanced CD-based hydrogels.