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Updated: Jul 8, 2025

Author Spotlight: Advancing Biopsy Techniques with Transesophageal Ultrasound
Published on: November 21, 2023
Using the Endoscope for Endobronchial Ultrasound in the Esophagus
Mohammad A Issa1, Paul F Clementsen2, Christian B Laursen3
1Pulmonary Research Unit (PLUZ), Department of Respiratory Medicine, Zealand University Hospital; moai@regionsjaelland.dk.
Endoscopic ultrasound-bronchoscopy (EUS-B) is a minimally invasive technique for pulmonologists to biopsy structures near the esophagus and stomach. This safe and feasible procedure expands diagnostic capabilities for lung cancer staging.
Area of Science:
- Pulmonology
- Interventional Pulmonology
- Gastroenterology
Background:
- Endoscopic ultrasound-bronchoscopy (EUS-B) utilizes an echoendobronchoscope for minimally invasive visualization and biopsy.
- It offers access to structures beyond traditional endoscopic ultrasound (EUS) and endobronchial ultrasound (EBUS).
- EUS-B is designed as a pulmonologist-friendly adaptation of EUS, leveraging existing EBUS expertise.
Purpose of the Study:
- To evaluate the safety and feasibility of EUS-B for pulmonologists.
- To assess the diagnostic expansion offered by EUS-B compared to existing methods.
- To highlight EUS-B's role in lung cancer diagnosis and staging.
Main Methods:
- The procedure involves introducing an echoendoscope through the nostril or mouth into the esophagus and stomach under conscious sedation.
- Key landmarks including the left liver lobe, abdominal aorta, left adrenal gland, and mediastinal lymph node stations (7, 4L, 4R) are identified using ultrasound.
- Biopsies are obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-B-FNA), with a specific biopsy order to prevent upstaging.
Main Results:
- EUS-B is demonstrated as a safe and feasible procedure for experienced interventional pulmonologists.
- The technique provides access to retroperitoneal lymph nodes, ascites, and lesions in the liver, pancreas, and adrenal gland, which are not reachable by EBUS.
- It allows for real-time ultrasonographic guidance for biopsies, similar to EBUS-TBNA.
Conclusions:
- EUS-B significantly expands diagnostic possibilities for pulmonologists.
- It offers a safe, fast, and thorough method for the diagnosis and staging of lung cancer.
- Training in EUS-B is considered a natural progression from EBUS, facilitating adoption by pulmonologists.
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