Prognostic factors in Hodgkin's disease

Between 1978-84 371 patients with HD were treated according to Protocol of LCG. 72.5% achieved complete, 10.8% partial remission and 16.7% were nonresponders. The evaluation of results was performed by PIL program from BMDP 81. The mean survival was 61 and disease-free survival (DFS) 60 months. The cumulative survival and DFS at 5 years were 65% and 68%, resp. Advanced HD, B symptoms, histopathology LD, male sex and age above 40 years influenced survival adversely. DFS decreased with CS III B, in males and age above 60 years significantly and in histopathology MC and LD with lack of significance. However, the size of mediastinal involvement was not a poor prognostic factor for survival, but influenced DFS. The prognostic value of major risk factors in HD was estimated by means of frequencies of their associations.