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Prognostic factors in Hodgkin's disease
Neoplasma
|January 1, 1986
Summary
This study on Hodgkin lymphoma (HD) found that while many patients achieved remission, advanced disease and certain patient factors negatively impacted survival and disease-free survival (DFS). Prognostic factors were identified for improved patient outcomes.
Area of Science:
- Oncology
- Clinical Medicine
- Hematology
Background:
- Hodgkin lymphoma (HD) treatment has evolved significantly.
- Understanding prognostic factors is crucial for optimizing patient management and outcomes.
Purpose of the Study:
- To evaluate the outcomes of 371 patients with Hodgkin lymphoma treated with the LCG protocol.
- To identify prognostic factors influencing survival and disease-free survival (DFS) in HD patients.
Main Methods:
- Retrospective analysis of 371 HD patients treated between 1978-1984.
- Statistical evaluation using the PIL program from BMDP 81.
- Assessment of prognostic factors including advanced disease, B symptoms, histopathology, sex, and age.
Main Results:
- Complete remission was achieved in 72.5% of patients; partial remission in 10.8%.
- Mean survival was 61 months, and 5-year survival was 65%.
- Advanced HD, B symptoms, LD histopathology, male sex, and age >40 years adversely affected survival; DFS was impacted by CS III B, male sex, age >60, and MC/LD histopathology.
Conclusions:
- The LCG protocol demonstrated significant remission rates in Hodgkin lymphoma.
- Several factors, including advanced disease stage and patient demographics, were identified as significant predictors of survival and DFS.
- Mediastinal involvement size was not a prognostic factor for survival but influenced DFS.